Join BJS Academy
BJS Academy>Randomized clinical ...>Intraoperative Wound...
Normal View Dyslexic View

Intraoperative Wound Irrigation for the Prevention of Surgical Site Infection After Laparotomy. A randomized clinical trial by CHIR-Net.

16 August 2024
Randomized clinical trials General
Mueller C, Kehl V, Dimpel R, Blankenstein C, Egert-Schwender SE, Strudthoff J, Lock JF et al, for the IOWISI Study Group.

JAMA Surg. 2024;159: 484-492.

This three armed RCT included 689 patients randomized to saline, polyhexanide or no wound irrigation. Respective wound infection rates were 12.5, 10.6 and 12.8 per cent. Compared to controls, polyhexanide did not reduce infection rates: hazard rate 1.23, 95 per cent confidence interval 0.64 to 2.36.

Comment: Wound irrigation remains controversial, and unproven.

BJS Foundation Limited
BJS Academy
0000-0000
BJS Foundation Limited
London, UK
rct270
Randomized clinical trials
Randomized clinical trials
General
Intraoperative Wound Irrigation for the Prevention of Surgical Site Infection After Laparotomy. A randomized clinical trial by CHIR-Net.
Mueller C, Kehl V, Dimpel R, Blankenstein C, Egert-Schwender SE, Strudthoff J, Lock JF et al, for the IOWISI Study Group.
16082024
JAMA Surg. 2024;159: 484-492.
This three armed RCT included 689 patients randomized to saline, polyhexanide or no wound irrigation. Respective wound infection rates were 12.5, 10.6 and 12.8 per cent. Compared to controls, polyhexanide did not reduce infection rates: hazard rate 1.23, 95 per cent confidence interval 0.64 to 2.36.
Comment: Wound irrigation remains controversial, and unproven.
Published on: 16 August 2024
Article ID: rct270

Related articles

Intrarenal pressure with hand-pump or pressurized-bag irrigation: randomized clinical trial at retrograde intrarenal surgery.

Croghan SM, O’Meara S, Cunnane EM, Purtill H, Walsh MT, O’Brien FJ et al.

7 August 2024

Efficacy and safety of bimekizumab in patients with moderate-to-severe hidradenitis suppurativa (BE HEARD I and BE HEARD II): two 48-week, randomised, double-blind, placebo-controlled, multicentre phase 3 trials.

Kimball AB, Jemec GBE, Sayed CJ, Kirby JS, Prens E, Ingram JR et al.

16 August 2024

Preoperative high dose of dexamethasone in emergency laparotomy: randomized clinical trial

Cihoric M, Kehlet H, Lauritsen ML, Højlund J, Kanstrup K, Kärnsund S et al.  

10 September 2024
  • Normal view
  • Dyslexic view
Copied!