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TEST-R-Doublet chemotherapy, triplet chemotherapy, or doublet chemotherapy combined with radiotherapy as neoadjuvant treatment for locally advanced oesophageal cancer (JCOG1109 NExT): a randomised, controlled, open-label, phase 3 trial.

Kato, K, Machida R, Ito Y, Daiko H, Ozawa S, Ogata T et al, on behalf of the JCOG1109 investigators.

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30 July 2025

HPB
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Onlay mesh versus suture repair for smaller umbilical hernias in adults—early results from SUMMER trial: randomized clinical trial

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2 May 2025

Hernia
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Impact of pre-compression versus non-compression before parenchyma transection in left-sided pancreatic resection on the rate of clinically relevant pancreatic fistula: multicentre randomized clinical trial

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2 May 2025

HPB
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Decellularized dermis allograft for the treatment of venous leg ulceration: the DAVE RCT

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2 May 2025

Vascular
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Gastric partitioning versus gastrojejunostomy for gastric outlet obstruction due to unresectable gastric cancer: randomized clinical trial

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2 May 2025

Upper GI
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Comparing the efficacy and safety of thromboprophylaxis with enoxaparin versus normal saline after liver transplantation: randomized clinical trial

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2 May 2025

VascularHPBTransplantation
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Axillary surgery versus no-axillary staging in T1N0 breast cancer: 20-year follow-up of the INT 09/98 randomized clinical trial

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2 May 2025

Breast
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Annual versus less frequent mammographic surveillance in people with breast cancer aged 50 years and older in the UK (Mammo-50): a multicentre, randomised, phase 3, non-inferiority trial

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22 April 2025

Breast
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Intravenous lidocaine for gut function recovery in colonic surgery. A randomized clinical trial

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22 April 2025

Colorectal
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Perioperative chemotherapy or preoperative chemoradiotherapy in esophageal cancer

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22 April 2025

Upper GI
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RCT of the Month

Appendicectomy versus antibiotics for acute uncomplicated appendicitis in children: an open-label, international, multicentre, randomised, non-inferiority trial

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6 March 2025

General
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Extent of lymphadenectomy for surgical management of right-sided colon cancer: the randomized phase III RELARC Trial

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17 February 2025

Colorectal
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Long-term results of 2-stage Turnbull-Cutait pull-through coloanal anastomosis for low rectal cancer

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17 February 2025

Colorectal
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Open retromuscular Sugarbaker vs keyhole mesh placement for parastomal hernia repair

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17 February 2025

Hernia
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Parastomal hernia prevention using funnel-shaped intra-abdominal mesh compared to no mesh. The Chimney randomized clinical trial

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17 February 2025

ColorectalHernia
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TransCatheter aortic valve implantation and fractional flow reserve-guided percutaneous coronary intervention versus conventional surgical aortic valve replacement and coronary bypass grafting for treatment of patients with aortic valve stenosis and complex or multivessel coronary disease (TCW): an international, multicentre, prospective, open-label, non-inferiority, randomised controlled trial

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17 February 2025

Vascular
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Neoadjuvant nivolumab and ipilimumab in resectable stage III melanoma

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17 February 2025

General
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Preoperative chemoradiotherapy for resectable gastric cancer

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20 January 2025

Upper GI
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Reductions in recurrence in women with early breast cancer entering clinical trials between 1990 and 2009: a pooled analysis of 155 746 women in 151 trials

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20 January 2025

Breast
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Tranexamic acid in patients undergoing liver resection: The HeLiX randomized clinical trial

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20 January 2025

HPB
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Screening for Helicobacter pylori to prevent gastric cancer: A pragmatic randomized clinical trial

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20 January 2025

Upper GI
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Long-term follow-up of the conventional versus no-touch isolation technique for resection of primary colon cancer (JCOG1006): randomized clinical trial 

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6 January 2025

Colorectal
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Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial.

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6 January 2025

HPB
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Continuous preperitoneal versus thoracic epidural analgesia in open pancreatoduodenectomy: randomized clinical trial

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6 January 2025

HPB
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