Join BJS Academy
BJS Academy>Randomized clinical ...>Upfront endoscopic n...
Normal View Dyslexic View

Upfront endoscopic necrosectomy or step-up endoscopic approach for infected necrotising pancreatitis (DESTIN): a single-blinded, multicentre, randomised trial.

16 August 2024
Randomized clinical trials HPB
Bang JY, Lakhtakia S, Thakkar S, Buxbaum JL, Waxman I, Sutton B et al, on behalf of the United States Pancreatic Disease Study Group.

Lancet Gastrohepatol 2024; 9: 22-33.

Seventy patients were included. Upfront necrosectomy resulted in fewer reinterventions (median 1 vs 2, P=0.003), but did not reduce mortality (none versus 2, respectively, P=0.22), or adverse events.

Comment: Smallish study, but indications of advantage for earlier intervention, rather than wait and see.

BJS Foundation Limited
BJS Academy
0000-0000
BJS Foundation Limited
London, UK
rct272
Randomized clinical trials
Randomized clinical trials
HPB
Upfront endoscopic necrosectomy or step-up endoscopic approach for infected necrotising pancreatitis (DESTIN): a single-blinded, multicentre, randomised trial.
Bang JY, Lakhtakia S, Thakkar S, Buxbaum JL, Waxman I, Sutton B et al, on behalf of the United States Pancreatic Disease Study Group.
16082024
Lancet Gastrohepatol 2024; 9: 22-33.
Seventy patients were included. Upfront necrosectomy resulted in fewer reinterventions (median 1 vs 2, P=0.003), but did not reduce mortality (none versus 2, respectively, P=0.22), or adverse events.
Comment: Smallish study, but indications of advantage for earlier intervention, rather than wait and see.
Published on: 16 August 2024
Article ID: rct272

Related articles

Temporary portocaval shunt provides superior intraoperative hemodynamics and reduces blood loss and duration of surgery in live donor liver transplantation. A randomized controlled trial.

Kumar M, Patil NS, Mohapatra N, Sindwani G, Dhingra U, Yadav A et al.
Ann Surg 2024; 279: 932-944.

16 August 2024

Neoadjuvant FOLFIRINOX versus upfront surgery for resectable pancreatic head cancer (NORPACT-1): a multicentre, randomised, phase 2 trial.

Labori KJ, Bratlie SO, Andersson B, Angelsen J-H, Biorserud C, Bjornsson B et al, for the Nordic Pancreatic Cancer Trial-1 study group.

30 August 2024

Pancreatoduodenectomy with or without prophylactic falciform ligament wrap around the hepatic artery for prevention of postpancreatectomy haemorrhage: randomized clinical trial (PANDA trial).

Welsch T, Müssle B, Korn S, Sturm D, Bork U.
Br J Surgery 2022; 109: 37-45.

1 January 2022
  • Normal view
  • Dyslexic view
Copied!